Amine Dehydrogenase (AmDH)
Description:
De Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzyme quod ammoniationem globi carbonyli catalyzare potest et ad amino globi redigere.NADH enzyme dependens est coenzyme, et NADH sicut transfusor hydrogenii agit.AmDH enzyme productorum genera sunt 4 (Number sicut ES-AmDH101～ES-AmDH104) a SyncoZymes evoluta, quae in aminatione aldehydes et ketonum possunt adhiberi reductivae regionis electivae vel stereoselectivae.
Genus reactionem catalytic:
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Substantiae Substantiae High.
Chiral selectivity strong.
Maximum conversionem.
★ Minus per-producta.
★ Mitis reactionis condiciones.
★ Environmentally amica.
➢ Communiter, ratio reactionis includit subiectum, solutionem quiddam, enzyme, coenzyme et coenzyme systematis regenerationis (eg glucose et dehydrogenasis glucose).
➢ AmDH in systemate reactionis novissime addi debet, post pH et temperatus condicionem reactionem adaptatam.
Exemplum 1 (Synthesis respondens chiralorum aminum per minutionem ketonum alkyl aryl)(1):
Custodi 2 annos infra -20℃.
Numquam attingunt extremas condiciones ut: caliditas, alta/humilis pH et altae concentrationes organicae solvendo.
1. Kong W, Liu Y, Huang C, et al.Angewandte Chemie International Edition, 2022: e202202264.
